Research data supporting "Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning"

Much evidence suggests that cognitive flexibility, which can be operationalized in reversal learning tasks, is mediated by cortico-striatal circuitries, with the orbitofrontal cortex (OFC) playing a prominent role. We investigated the effects on reversal learning of pharmacological overactivation of the lateral and medial orbitofrontal cortex (lOFC, mOFC) using a glutamate transporter 1 (GLT-1) inhibitor, dihydrokainate (DHK), which increases extracellular glutamate by blocking its reuptake. We also tested the impact of antagonism of the serotonin 2A receptor (5-HT2AR), which modulates glutamate action, in the mOFC and lOFC on the same task. Each .csv file corresponds to one experiment: reversal learning data from mOFC & lOFC, with rats receiving either the glutamate transporter 1 (GLT-1) inhibitor, dihydrokainate (DHK) or the antagonist of the serotonin 2A receptor (M-100,907).This work was supported by a Wellcome Trust Senior Investigator Grant to TWR (104631/Z/14/Z) and a Lundbeck Foundation Research Fellowship to MEH (R182-2014–2810 and R210-2015–2982)